Association between brain iron deposition and pure apathy in Parkinson's disease: a cross-sectional quantitative susceptibility mapping imaging study.

ABSTRACT:

Background

Apathy, a decline in goal-directed motivated behavior, is a common non-motor symptom (NMS) in Parkinson's disease (PD). Previous studies have suggested that PD patients with apathy exhibit increased iron levels in the cerebrospinal fluid (CSF) and the iron levels are positively correlated with the severity of apathy, indicating that apathy in PD may be related with brain iron accumulation. Specifically, quantitative susceptibility mapping (QSM), an emerging brain magnetic resonance imaging (MRI) technique, can be used to sensitively detect the iron deposition in the brain in vivo, to reflect the neurodegeneration processes. This study thus used QSM to detect the brain iron deposition in PD with pure apathy (PD-PA) and examined apathy symptoms-related regional brai

SUBMITTER: Zhang L 

PROVIDER: S-EPMC12397670 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature