Fractional flow reserve calculation optimized by myocardial computed tomography perfusion information.

ABSTRACT:

Background

Current computed tomography angiography-derived fractional flow reserve (CT-FFR) diagnosis leaves room for improvement in diagnosing coronary heart disease. In this study, the computed fluid dynamics boundary condition optimization method was used to calculate CT-FFR aiming to improve the diagnostic accuracy of CT-FFR for coronary heart disease.

Methods

The two enhancement approaches are as follows: (A) inlet flow optimization, which involves determining the total coronary inlet flow rate by summing the myocardial blood flow (MBF) across the entire left ventricular myocardium; and (B) inlet & outlet flow optimization: building upon method A, where the outlet flow of coronary artery branches is calculated through blood supply area analysis.

Results

A total o

SUBMITTER: Qin P 

PROVIDER: S-EPMC12397671 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature