Disruptions of morphological brain networks and their associations with multi-symptoms in children with spastic cerebral palsy.

ABSTRACT:

Background

Spastic cerebral palsy (SCP) is associated with extensive alterations in regional cortical morphology. However, the specific effects of SCP on the topological organization of morphological brain networks remain largely unknown. This study aimed to investigate these effects and explore their potential correlations with clinical manifestations in SCP children.

Methods

Structural magnetic resonance imaging and clinical data were collected from 31 children with SCP and 29 sex- and age-matched children with typical development. Single-subject morphological brain networks were constructed separately based on four different morphological indices [i.e., the cortical thickness (CT), fractal dimension, gyrification index, and sulcus depth], which were further characterized

SUBMITTER: Zhao C 

PROVIDER: S-EPMC12397673 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature