An exploratory study of the diffusion tensor imaging analysis along perivascular spaces (DTI-ALPS) index combined with quantitative analysis of choroid plexus volume and perivascular spaces in different cognitive stages of cerebral small vessel disease.

ABSTRACT:

Background

Cerebral small vessel disease (CSVD) is a major contributor to cognitive impairment and dementia. Growing evidence suggests that impaired perivascular clearance plays a pivotal role in CSVD pathogenesis, yet non-invasive biomarkers for early cognitive decline remain limited. This study aimed to explore the diagnostic value of the diffusion tensor imaging analysis along perivascular spaces (DTI-ALPS) index, enlarged perivascular spaces (EPVS) numbers/volume, and choroid plexus volume (CPV) across different cognitive stages of CSVD.

Methods

We retrospectively analyzed data from 102 CSVD patients [33 CSVD-cognitive normal (CSVD-CN); 39 CSVD-mild cognitive impairment (CSVD-MCI); 30 vascular dementia (VaD)] and 29 normal controls (NCs). Quantitative measurements of the

SUBMITTER: Lu W 

PROVIDER: S-EPMC12397676 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature