Abnormal structural changes and disturbed functional connectivity in patients with Crohn's disease and abdominal pain: a voxel-based morphometry and functional magnetic resonance imaging study.

ABSTRACT:

Background

Abdominal pain is a prevalent and debilitating manifestation of Crohn's disease (CD) that significantly impacts the lives of those affected. The neurological pathways responsible for abdominal pain in patients with CD remain unidentified. Therefore, the purpose of this study was to characterize the structural alterations in the brain and associated functional connectivity (FC) in patients with CD and abdominal pain.

Methods

The data for three-dimensional T1-weighted and resting-state functional magnetic resonance imaging (fMRI) were gathered from 23 patients with CD and abdominal pain (pain CD), 24 patients with CD but without abdominal pain (nonpain CD), and 25 healthy controls (HCs). Differences in gray-matter volume (GMV) and FC between the pain CD group, nonpa

SUBMITTER: Wu X 

PROVIDER: S-EPMC12397677 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature