Endotoxemia-Induced Inflammation in the Absence of Obesity Is Associated With Decreased Anxiety-Like and Impulsive Behavior With no Effect on Learning and Memory.

ABSTRACT: Obesity is associated with increased gut permeability, which contributes to a state of chronic low-grade inflammation. Obesity is also linked with altered neurocognitive functions, including impaired learning and memory. Whether these changes are secondary to neuroinflammation versus other comorbidities associated with obesity is unknown. Here, we modeled the chronic low-grade inflammation that accompanies diet-induced obesity, but in the absence of obesity or consumption of an obesogenic diet. Male rats were implanted with intraperitoneal osmotic minipumps, continuously dispensing either saline (control) or lipopolysaccharide (LPS), an endotoxin produced in the gut that triggers inflammation when in circulation. Immunohistochemistry results revealed that LPS exposure led to neuroinflammat

SUBMITTER: Klug ME 

PROVIDER: S-EPMC12397682 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature