Comparison of [⁶⁸Ga]Ga-FAPI-04 and [¹⁸F]FDG PET/CT for detection of bone metastases of lung cancer.

ABSTRACT:

Background

Bone metastases of lung cancer typically indicate disease progression and poor prognosis. Early and accurate detection is crucial for staging, treatment planning, and prognostic evaluation. This study aimed to compare the diagnostic value of gallium 68-labeled fibroblast-activation protein inhibitor-04 ([⁶⁸Ga]Ga-FAPI-04) and fluorine 18-labeled fluorodeoxyglucose ([¹⁸F]FDG) positron-emission tomography/computed tomography (PET/CT) imaging in detecting bone metastases in lung cancer.

Methods

A retrospective analysis was conducted on patients with pathologically confirmed lung cancer and clinically suspected bone metastases. These patients underwent both [⁶⁸Ga]Ga-FAPI-04 and [¹⁸F]FDG PET/CT imaging. Initially, all patient

SUBMITTER: Wu J 

PROVIDER: S-EPMC12397704 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature