Zinc methionine mitigates intestinal mucosal injury of broilers challenged with Salmonella by modulating mucus secretion, tight junction and microbial composition.

ABSTRACT: The investigation aimed to reveal potential mechanisms of zinc methionine on the intestinal mucosal function of Salmonella-challenged broilers. Totally, 320 Ross 308 male chicks were divided into 4 treatments, with 8 repetition per group and 10 chicks each. A 2 × 2 factor in a randomized block design was employed to explore the impacts of zinc addition, Salmonella challenge, and their interactions. The experiment lasted for 21 days. Results indicated that Salmonella infection decreased (P < 0.05) average daily gain (ADG) and the ratio of villus height to crypt depth (V/C) in both jejunum and ileum. The infection also reduced (P < 0.05) MUC2 and KLF4 mRNA levels, while elevating (P < 0.05) feed to gain (F:G), caudal-related homeobox transcriptional regulator 2 (CDX2) mRNA level, and alterin

SUBMITTER: Shao Y 

PROVIDER: S-EPMC12397860 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature