Assessment of Variable Traveling Wave Profiles for Small-Molecule Applications in Ion Mobility Spectrometry-Mass Spectrometry (IMS-MS).

ABSTRACT: The MOBILion MOBIE system is a relatively new platform offering high ion mobility spectrometry (IMS) resolving power and resolution. While these advancements present encouraging opportunities for isomer separations and improved molecular annotation, previous studies have noted that collision cross section (CCS) values collected on the MOBIE and other traveling wave (TW) systems possess bias in calculated CCS values that limits the functionality of translating CCS libraries across multiple IMS platforms. Though these challenges persist, MOBILion recently released a software update (EyeOn v.2.3) that provides the capability of utilizing variable traveling wave profiles, which modulate the applied TW amplitude and frequency over the duration of each IMS scan to provide optimal transmission, I

SUBMITTER: Dodds JN 

PROVIDER: S-EPMC12397904 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature