An evolutionarily conserved role for CTNNB1/β-CATENIN in regulating the development of the corpus callosum.

ABSTRACT: The corpus callosum (CC) is a major nerve bundle that connects the two hemispheres of the brain. Dysgenesis of the CC is associated with neurodevelopmental disorders such as the CTNNB1 syndrome. We identified that five individuals carrying CTNNB1 mutations displayed CC deficits. To explore CTNNB1/β-CATENIN-dependent mechanisms that regulate CC midline crossing, we examined mice with Ctnnb1 gain of function (GOF) or loss of function (LOF) selectively targeted to the early embryonic central nervous system midline using an Lmx1aCre driver. We identify that the Lmx1a lineage contributes to midline cell populations known to regulate CC pathfinding: the glial wedge, the indusium griseum glia, and a population of midline glutamatergic neurons. We find that each of these structures a

SUBMITTER: Parichha A 

PROVIDER: S-EPMC12397918 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature