Remote Ischemic Preconditioning Prevents Acute Kidney Injury Following Coronary Angiography: The BRICK Randomized Clinical Trial.

ABSTRACT: Patients undergoing invasive coronary angiography have an increased risk of acute kidney injury (AKI) for which there is no well-defined prophylactic therapy. This study examined whether remote ischemic preconditioning (RIPC) reduces the rate of AKI in high-risk patients undergoing invasive coronary angiography. In this randomized sham-controlled trial, we enrolled high-risk patients undergoing coronary angiography between March 2018 and February 2023. Patients were randomly assigned 1:1 to RIPC or sham-RIPC. The primary outcome was the rate of AKI after coronary angiography. Secondary endpoints included changes in vascular and urinary biomarkers after RIPC, major adverse cardiovascular and cerebrovascular events (MACCE), and major adverse kidney events at 6-month follow-up. A total of 109

SUBMITTER: Olafiranye O 

PROVIDER: S-EPMC12397924 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature