Variation in Venous Thromboembolism Outcomes Based on Primary Cancer Site: A RIETE Registry Analysis.

ABSTRACT: Patients with cancer-associated venous thromboembolism (VTE) are at increased risk of both recurrent VTE and bleeding. These risks may vary by cancer site, but the magnitude of this variation remains unclear. The aim of the study was to compare 90-day risks of recurrent VTE or VTE-related death (composite outcome) and major bleeding across different cancer sites. We analyzed 18,660 patients with active cancer and VTE and 88,162 without cancer in the RIETE (Registro Informatizado de la Enfermedad Tromboembólica) registry. Multivariable Cox models and Fine-Gray competing risk analyses were used. Sensitivity analyses included propensity score matching and subgroup stratification by cancer site. Within 90 days, 4.0% of cancer-associated thrombosis patients experienced the composite outcome (fa

SUBMITTER: Trujillo-Santos J 

PROVIDER: S-EPMC12397929 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature