Lactulose Combined With PEG for Effective and Safe Bowel Preparation Before Colonoscopy: A Meta-Analysis.

ABSTRACT:

Objective

To compare the efficacy of polyethylene glycol electrolyte (PEG) combined with lactulose versus PEG alone in bowel preparation quality for colonoscopy.

Methods

The protocol for this systematic review was registered with PROSPERO (CRD420251035139). Comprehensive literature searches were conducted across multiple databases, including PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), Wanfang Data, and VIP. RevMan 5.4 software was employed to assess differences between the two groups regarding the rates of excellent bowel preparation, willingness to undergo repeat examination, incidence of adverse reactions, and adenoma detection rates.

Results

Sixteen eligible studies, encompassing 2468 participants, were included

SUBMITTER: Xia HB 

PROVIDER: S-EPMC12397949 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature