Adipocytes Impair Mitoxantrone Cytotoxicity Against Acute Lymphoblastic Leukemia.

ABSTRACT:

Introduction

Obesity contributes to poorer clinical outcomes in patients with acute lymphoblastic leukemia. We have shown that adipocytes cause anthracycline resistance by absorbing and metabolizing them into less-active alcohol metabolites.

Methods

We hypothesized that mitoxantrone, which has a similar cytotoxic mechanism to anthracyclines but is metabolized through different pathways, might overcome this adipocyte-mediated chemoresistance. We treated human BV173 acute lymphoblastic leukemia cells with daunorubicin and mitoxantrone that had been incubated with or without 3T3-L1 adipocytes.

Results

Contrary to our hypothesis, adipocytes induced similar chemoresistance to both drugs.

Conclusion

Mitoxantrone is unlikely to be an attractive alternative to overcome

SUBMITTER: Cohen M 

PROVIDER: S-EPMC12397950 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature