Anesthesia alters complexity of spontaneous and stimulus-related neuronal firing patterns in rat visual cortex.

ABSTRACT: Complexity of neuronal firing patterns may serve as an indicator of sensory information processing across different states of consciousness. Recent studies have shown that spontaneous changes in brain states can occur during general anesthesia, which may influence neuronal complexity and the state of consciousness. In this study, we investigated how the firing patterns of cortical neurons, both at rest and during visual stimulation, are affected by spontaneously changing brain states under varying levels of anesthesia. Extracellular unit activity was measured in the primary visual cortex of unrestrained rats as the inhaled concentration of desflurane was incrementally reduced to 6%, 4%, 2%, and 0%. Using dimensionality reduction and density-based clustering on individual unit activities, w

SUBMITTER: Li D 

PROVIDER: S-EPMC12397990 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature