Plasma proteomics in septic shock and alcohol-related pancreatitis: a hyaluronan-centered approach.

ABSTRACT:

Background

Sepsis is a critical condition characterized by a dysregulated immune response to infection. As sepsis develops to septic shock, its most severe form, morbidity and mortality increases. Hyaluronan is a key component of the extracellular matrix and the endothelial glycocalyx. In sepsis, plasma hyaluronan concentrations are increased and correlate with disease severity. In this study we aimed to explore and compare the proteomic profiles of hyaluronan-associated proteins in patients with the dysregulated immune response of septic shock and the sterile inflammation of acute alcohol-related pancreatitis.

Methods

The present study involved proteomic analysis of patients with septic shock (n = 13), pancreatitis (n = 8), and healthy controls (n = 8). LC-MS/MS was conduct

SUBMITTER: van der Heijden J 

PROVIDER: S-EPMC12398169 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature