Association between the dietary index for gut microbiota and osteoporosis among middle-aged and older adults in the United States.

ABSTRACT: Objective: Osteoporosis is an age-related disease, and the gut microbiota plays a crucial role in regulating bone mineral density (BMD) through modulating nutrient absorption, immunity, and bone metabolism. This research examines the association between the dietary index for gut microbiota (DI-GM) and osteoporosis prevalence among US middle-aged and older adults. Methods: We included 7255 middle-aged and elderly adults from the National Health and Nutrition Examination Survey (NHANES) 2007-2020. The DI-GM was calculated based on 14 dietary components associated with gut microbiota health. Osteoporosis was defined by femoral neck BMD T-score ≤ -2.5. Multivariable logistic regression and restricted cubic spline (RCS) models were employed to examine the relationship between DI-G

SUBMITTER: Zhan Y 

PROVIDER: S-EPMC12398234 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature