A retrospective analysis of neoadjuvant chemotherapy in pneumonectomy for locally advanced central non-small cell lung cancer.

ABSTRACT:

Aims

The treatment of patients with locally advanced central non-small cell lung cancer (NSCLC) remains controversial. This study aimed to evaluate the effects of neoadjuvant chemotherapy in patients undergoing pneumonectomy.

Methods

A retrospective analysis was conducted on patients who underwent pneumonectomy with or without neoadjuvant chemotherapy for locally advanced central NSCLC between 2014 and 2019. Categorical variables were compared using the Chi-square or Fisher's exact test. Survival analysis was performed using the Kaplan-Meier method, with comparisons made via the log-rank test. Multivariate analysis of independent prognostic factors was conducted using the Cox proportional hazards regression model. A p-value < 0.05 was considered statistically s

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12398283 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature