A Photoinducible DNA Cross-Linking Agent with Potent Cytotoxicity and Selectivity Toward Triple-Negative Breast Cancer Cell Line.

ABSTRACT: DNA interstrand cross-links (ICLs) are the sources of the cytotoxicity of many anticancer agents. Selenium compounds showed great potential as anticancer drugs. In this work, we synthesized a binaphthalene analog 1 containing phenyl selenide (-SePh) as the leaving group and investigated its photochemical reactivity toward DNA as well as its cytotoxicity and selectivity. DNA ICLs were not observed with binaphthalene phenyl selenide 1 without UV irradiation, while ∼15% DNA ICL products were detected with UV irradiation, indicating a photoresponsive property of 1. The trapping reactions with TEMPO and MeONH₂, respectively, suggested that free radicals and carbocations are involved in the DNA cross-linking process induced by the photoirradiation of 1. The

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC12398329 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature