Organ Failure, Endotoxin Activity, and Mortality in Septic Shock.

ABSTRACT:

Importance

The relationship between endotoxin activity, organ failure, and mortality is not well understood.

Objective

To test whether the combination of endotoxin activity and organ failure identifies patients at higher risk of death from sepsis and determine the relationship to previously described sepsis phenotypes.

Design, setting, and participants

Prospective observational study in four ICUs enrolling critically ill patients with septic shock.

Main outcomes and measures

Endotoxin activity assay (EAA) results, Sequential Organ Failure Assessment (SOFA), and multiple organ dysfunction (MODS) and 28-day mortality.

Results

We enrolled 90 patients aged 25-95 years and set an EAA cutoff of greater than or equal to 0.6 together with SOFA greater than 11 or

SUBMITTER: Molinari L 

PROVIDER: S-EPMC12398369 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature