Dimensional foundations toward a novel nosology addressing comorbidity: Preadolescent syndrome profiles.

ABSTRACT:

Objective

Traditional categorical systems for diagnosing psychopathological symptoms, such as the DSM-5, face limitations including high comorbidity rates and insufficient support for transdiagnostic treatment protocols. Dimensional, person-centered approaches can address these limitations by focusing on cross-cutting psychiatric symptoms.

Method

This study leverages data from the Adolescent Brain Cognitive Development℠ Study (ABCD Study®) to develop dimensional models of preadolescent psychopathology, focusing on a large, diverse sample of youths aged 9-10. We used latent profile analysis (LPA) on Child Behavior Checklist (CBCL) syndrome scales collected from an elevated symptomatology subsample to delineate subgroups for targeted interventions.

Results

Four distinct

SUBMITTER: Walker JC 

PROVIDER: S-EPMC12398404 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature