Bioinformatics Analysis Reveals the Oncogenic Role and Therapeutic Potential of lncRNA SNHG25 in Colon Adenocarcinoma.

ABSTRACT: Background: Colon adenocarcinoma (COAD) is a common digestive malignancy with limited therapies and a poor prognosis. Previous studies have highlighted lncRNAs' key role in cancer, but the exact function of lncRNA SNHG25 in COAD remains unclear. Methods: In this study, we obtained COAD transcriptome data from the UCSC Xena database, screened for differentially expressed genes, and assessed the diagnostic efficacy of SNHG25 using the DESeq2 package. Subsequently, the SNHG25 high- and low-expression groups were enriched and analyzed for immune cell infiltration characteristics and correlation with SNHG25 using the CIBERSORT and ESTIMATE algorithms. Its impact on immunotherapy and drug sensitivity was assessed by combining TIDE with oncoPredict databa

SUBMITTER: Hao R 

PROVIDER: S-EPMC12398412 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature