Assessment of first-trimester insulin resistance indices for gestational diabetes mellitus: a prospective cohort study.

ABSTRACT:

Background

Insulin resistance (IR) is a significant factor in gestational diabetes mellitus (GDM) development. The triglyceride-glucose (TyG) index, triglyceride-glucose body mass index (TyG-BMI), atherogenic index of plasma (AIP), and metabolic score for insulin resistance (METS-IR) are simple and reliable surrogates for assessing IR, but their predictive potential for GDM remains unexplored.

Methods

Data from 46,992 singleton pregnancies delivered at Beijing Obstetrics and Gynecology Hospital between 2018 and 2022 were prospectively collected. IR indices were calculated using first-trimester blood lipid and glucose measurements. Participants were classified into GDM and non-GDM groups based on oral glucose tolerance test (OGTT) results at 24-28 weeks. Logistic regression a

SUBMITTER: Zhang L 

PROVIDER: S-EPMC12398428 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature