Title: Medium-Term Lag-Response Associations Between PM₁₀ Exposure and All-Cause Mortality in Valencia and London: A Time-Stratified Case-Crossover Study.

ABSTRACT:

Background

Air pollution is among the top five environmental risk factors for human health worldwide. However, our understanding of the physiological responses to PM₁₀ exposure over medium-term lag periods remains limited. This study aims to examine the medium-term lag-response associations-using lagging time windows of up to 21 days-between PM₁₀ exposure and all-cause mortality in Valencia and London from 2002 to 2006.

Methods

We used a time-stratified case-crossover design; building on the methodologies of Tobias et al. and Bhaskaran et al., we applied a fixed-effects conditional quasi-Poisson regression model to quantify the association between PM₁₀ exposure and all-cause mortality. We also analyzed three different temporal lag methodologi

SUBMITTER: Zhou B 

PROVIDER: S-EPMC12398449 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature