An MRI-based model for preoperative prediction of tertiary lymphoid structures in patients with gallbladder cancer.

ABSTRACT:

Objectives

To predict tertiary lymphoid structures (TLSs) in gallbladder cancer (GBC) using preoperative magnetic resonance imaging (MRI)-based radiomics.

Methods

Patients with GBC from two centres served as training (n = 129) and external validation (n = 44) cohorts. Radiomics features were extracted from six imaging sequences for inclusion in a radiomics model (Rad-score). Univariate and multivariate logistic regression were used to identify independent clinico-radiological predictors of TLS status. The clinical and radiomics models were integrated into a combined model. Areas under receiver operating characteristic curves (AUC) were used to assess model performance. The combined model was divided into low- and high-risk according to the cut-off value determined by the max

SUBMITTER: Xu Y 

PROVIDER: S-EPMC12398454 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature