Notch2-expressing CD4⁺ T cells attain immunoregulatory functions during autoimmune inflammation.

ABSTRACT: Autoantigen-specific CD4⁺ T cells are central to the development of autoimmune diseases, while the expansion of regulatory T (Treg) cells expressing Forkhead box protein 3 (Foxp3) is essential for mitigating these conditions. In this study, we identified CD4⁺Notch2⁺Foxp3^lo T cells in the spinal cords of mice with experimental autoimmune encephalomyelitis (EAE), dextran sodium sulfate-induced colitis model mice, and patients with ulcerative colitis as immune regulatory cells. These cells exhibited a nonproliferative, dysfunctional phenotype and demonstrated immune regulatory functions, including suppressive activity against activated CD4⁺ T cells and marked Treg cell expansion activity. Our data revealed that Notch2 deletion in Foxp3-ex

SUBMITTER: Bae SE 

PROVIDER: S-EPMC12398495 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature