Structure and transport mechanism of the human prostaglandin transporter SLCO2A1.

ABSTRACT: SLCO2A1 is a member of the organic anion transporting polypeptide (OATP) family, which preferentially transports prostaglandins (PGs) into cells and plays a vital role in regulating PGs inactivation and distribution. Dysregulation or genetic mutation of SLCO2A1 is associated with primary hypertrophic osteoarthropathy (PHO) and chronic enteropathy associated with the SLCO2A1 gene (CEAS). Although the biophysical and biochemical properties of SLCO2A1 have been characterized, the precise mechanism by which SLCO2A1 recognizes and transports PGs remains unclear. Here, we present the cryo-electron microscopy structures of human SLCO2A1 in apo and PGE₂-bound forms, revealing the detailed structural features and structural basis for PGs transport. Fatty acid-like PGE₂ binds i

SUBMITTER: Xia Z 

PROVIDER: S-EPMC12398505 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature