Circulating miRNAs as potentially predictive biomarkers for chemoimmunotherapy in advanced biliary tract cancer: a post-hoc analysis of the phase II T1219 study.

ABSTRACT: Circulating microRNAs (miRNAs) have not been investigated as predictive biomarkers in patients with advanced biliary tract cancer (ABTC) who received chemoimmunotherapy. In the single-arm phase II T1219 trial, 46 patients with ABTC received first-line nivolumab, gemcitabine, and S-1 treatment. Plasma samples were prospectively collected at baseline and 6 weeks after treatment for miRNA profiling. Among the 167 miRNAs analyzed, the baseline levels of hsa-miR-16-5p, hsa-miR-93-5p, and hsa-miR-126-3p were significantly elevated in the responders. High hsa-miR-16-5p expression was correlated with longer progression-free survival (hazard ratio [HR] = 0.44, 95% confidence interval [CI] = 0.12-0.85, p = 0.025) and overall survival (HR = 0.34, 95% CI = 0.07-0.7, p = 0.01). Post-treatment miRNA cha

SUBMITTER: Chiang NJ 

PROVIDER: S-EPMC12398617 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature