Antiplasmodial activity of pentyloxyamide-based histone deacetylase inhibitors against Plasmodium falciparum parasites.

ABSTRACT: Malaria is caused by Plasmodium parasites and remains a significant health concern for almost half the world's population. There are estimated to be > 240 million malaria cases and approximately 600,000 malaria-related deaths annually, mainly due to infection with P. falciparum parasites. Parasite drug resistance is impacting malaria prevention and control efforts, and as part of the malaria eradication agenda, new drugs with novel mechanisms of action are needed. Histone/lysine deacetylase (HDAC) enzymes play essential roles in Plasmodium biology and are potential targets for the development of new antiplasmodial agents. In this study, a panel of 24 HDAC inhibitors with hydroxamic acid zinc binding group, a pentyloxyamide connecting unit linker region and substituted 4-phenyl and 4(pyridi

SUBMITTER: Dawood WA 

PROVIDER: S-EPMC12398779 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature