Therapeutic effects of Gunryeong-tang on the cardio-renal axis in an animal model of pulmonary hypertension.

ABSTRACT: Background: In the realm of cardiovascular and renal health, the modulation of oxidative stress and inflammation within the cardio-renal axis plays a pivotal role. This study investigates the therapeutic potential of Gunryeong-tang (GRT), a traditional Korean herbal formula combining Oryeongsan (Wulingsan) and Sagunza-tang (Sijunzi-tang), specifically in addressing cardio-renal axis dysfunction induced by pulmonary arterial hypertension (PAH-r). Methods: PAH-r models were induced through intraperitoneal injection of monocrotaline (MCT) at a daily dose of 50 mg/kg for 5 days to simulate pulmonary hypertension, a common cause of cardio-renal syndrome. The primary focus is on evaluating its anti-fibroinflammatory effects and its ability to modulate oxidative stress and inflammat

SUBMITTER: Na SW 

PROVIDER: S-EPMC12398790 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature