Intestinal short-chain fatty acid turnover is not associated with resting state functional connectivity in mesolimbic dopaminergic network in healthy adults.

ABSTRACT: People with obesity tend to have altered functional connectivity of reward-related areas in the brain, contributing to overeating and weight gain. The gut-brain axis may function as a mediating factor, with gut-derived short-chain fatty acids (SCFAs) as possible intermediates in the relationship between microbiota and functional connectivity. We investigated the influence of SCFA turnover on resting state functional connectivity in healthy individuals with extremely high and extremely low levels of intestinal SCFA turnover. In this study, we included individuals with low or high intestinal SCFA turnover (estimated by fecal concentration of the butyryl-coenzyme A (CoA)-transferase (ButCoA) gene). Resting state functional magnetic resonance imaging (rs-fMRI) was used to assess functional con

SUBMITTER: Wijdeveld M 

PROVIDER: S-EPMC12398794 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature