Mapping iron content and white matter integrity in the anterior thalamic radiations across Huntington's disease stages.

ABSTRACT: Huntington's disease (HD) is characterized by progressive neurodegeneration, often accompanied by disrupted iron regulation and altered white matter (WM) integrity. This study investigates iron content and microstructural changes in the anterior thalamic radiations (ATR) across different HD stages. Thirty-one gene carriers and twenty-four controls underwent neuropsychological assessment and 3 T-MRI scanning, including relaxometry and diffusion tensor imaging (DTI) sequences to assess iron content and WM microstructure. ATR changes were examined using average and along-the-tract analyses, with ANOVA and post-hoc Tukey tests to identify group differences and Spearman correlations to evaluate clinical associations. Machine-learning models were applied to assess the potential of MRI metrics as

SUBMITTER: Domingo-Ayllon M 

PROVIDER: S-EPMC12398804 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature