Salivary Biomarkers for Oral Frailty in Patients With Burning Mouth Symptoms.

ABSTRACT:

Objective

Despite its relevance to physical frailty, the pathophysiological mechanisms underlying oral frailty remain poorly understood. This study aimed to investigate salivary biomarkers associated with oral frailty.

Methods

Ninety-eight postmenopausal women (mean age, 65.2 ± 7.2 years) with burning mouth symptoms were included in this study. This study was conducted as an ancillary analysis of our previous cohort. Oral frailty was assessed using a validated 4-point scale for difficulties in chewing, speaking, and swallowing. The levels of inflammatory and oxidative stress biomarkers, stress hormones, and female gonadal hormones were measured using unstimulated (UWS) and stimulated whole saliva (SWS) samples. Blood biomarkers were assessed using complete blood counts. Oral

SUBMITTER: Kim SM 

PROVIDER: S-EPMC12398832 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature