Prognostic value of baseline plasma D-dimer levels in sepsis: a prospective cohort study.

ABSTRACT:

Background

Plasma D-dimer, a fibrin degradation product, reflects coagulation activation and is often elevated in critically ill patients. Its prognostic significance in sepsis, particularly for short-term outcomes, remains unclear.

Methods

In this prospective cohort study, we enrolled 175 adult ICU patients with sepsis (Sepsis-3 criteria) from March 2024 to February 2025. Plasma D-dimer levels were measured at ICU admission and daily for five days. D-dimer levels were categorized into quartiles. The primary outcome was 30-day all-cause mortality; secondary outcome was in-hospital septic shock. Associations were analyzed using Cox regression, Kaplan-Meier analysis, and subgroup analysis.

Results

Elevated admission D-dimer levels were significantly associated with incr

SUBMITTER: Qu X 

PROVIDER: S-EPMC12398842 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature