A tumor microenvironment-responsive Zr-MOF nanosystem for co-delivering siHIF-1α and triptolide enhances photodynamic therapy in esophageal cancer by amplifying ROS generation and reversing hypoxia.

ABSTRACT: In addition to early diagnosis and on-time treatment, the adoption of new therapeutic strategies is of great significance for improving the clinical outcomes of patients with esophageal cancer. Although emerging therapies such as photothermal and photodynamic therapy (PDT) can precisely eliminate cancer cells and are alternative strategies to conventional treatments, hypoxia status of solid tumors have hindered their application. In recent years, nanoplatforms have been developed to address these limitations and improve the efficacy and safety of treatments. In addition, triptolide (TPL) and HIF-1α silencing may have potential value in cancer treatment by regulating oxidative stress. Inspired by these findings, we designed a cancer cell membrane-camouflaged porphyrin (photosensitizer) meta

SUBMITTER: Liu W 

PROVIDER: S-EPMC12398845 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature