Investigating cytotoxic and inflammatory human IL-7 receptor low effector memory CD8⁺ T cells in lupus.

ABSTRACT: This study aims to interrogate the implications of CD8+ T cells in lupus by examining CD8+ T cell heterogeneity and assessing the significance of this heterogeneity in promoting inflammation and tissue damage. Our own and publicly available RNA-seq and microarray data from the peripheral blood and kidney tissues of patients with lupus were analysed. Imaging Mass Cytometry (IMC) analysis of immune cells was conducted in lupus and normal kidney tissues. The effects of CD8+ T cell subsets on neutrophils were evaluated ex vivo. Our scRNA-seq analysis showed an accumulation of effector memory (EM) CD8+ T cell subsets that expressed low levels of the IL7 receptor gene (IL7Rlow) but high levels of effector molecule genes, including GZMB, GZMK, PRF1, and GNLY, in the peripheral blood and kidneys o

SUBMITTER: Lee SJ 

PROVIDER: S-EPMC12398881 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature