An intelligent closed-loop CES for depression treatment using brain signals and machine learning.

ABSTRACT: This method presents a double-blind, randomized, parallel-group clinical trial aimed at personalizing cranial electrotherapy stimulation (CES) according to individual brain signals, assessing the effect of Intelligent Closed-Loop Cranial Electrotherapy Stimulation (IC-CES) on Major Depressive Disorder (MDD). Objective: To evaluate the effectiveness of IC-CES in treating MDD. Design: 120 participants were randomly assigned to either the IC-CES group or the CES group. Assessment: Depression, anxiety, and sleep quality were measured at multiple time points using standard questionnaires.

SUBMITTER: Mosayebinejad F 

PROVIDER: S-EPMC12398912 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature