<i>Houttuynia cordata</i> triggers type I interferon signaling to promote host defense against <i>Acinetobacter baumannii</i> infection via mTORC1 activation.

ABSTRACT: Multidrug-resistant Acinetobacter baumannii, a prevalent opportunistic pathogen in hospitals, presents a substantial risk to immunocompromised patients, triggering life-threatening conditions including pneumonia, bacteremia, and sepsis, which can be fatal. Therefore, it is urgent to develop new therapeutic strategies to combat and eradicate multidrug-resistant A. baumannii infection. Our finding reveals that Houttuynia cordata promotes the mice treated with 5-fluorouracil (5-FU) to defend against multidrug-resistant A. baumannii infection via the mTORC1-IFN-I signaling pathway. Mechanistically, Houttuynia cordata triggers mTORC1 activation through the phosphorylation of p38 MAPK, and mTORC1 is required for the subsequent activation of IFN-I signaling path

SUBMITTER: Xie Q 

PROVIDER: S-EPMC12398920 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature