Treatment outcome is associated with pre-treatment connectome measures across psychiatric disorders - evidence for connectomic reserve?

ABSTRACT: Predicting treatment efficacy in psychiatric disorders remains challenging, despite the availability of effective interventions. Previous studies suggest a link between pre-treatment brain network characteristics and treatment efficacy in individual disorders, but cross-disorder investigations are lacking. We analyzed pre-treatment MRI data from 177 individuals (113 females) with either obsessive-compulsive disorder (OCD) or post-traumatic stress disorder with comorbid personality disorders (PTSD) that received different non-pharmacological treatments. Using diffusion and resting-state MRI, we constructed structural, functional, and multilayer connectomes and calculated network measures for network integration (e.g. global efficiency, eccentricity), segregation (modularity) and their balan

SUBMITTER: Vriend C 

PROVIDER: S-EPMC12398921 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature