Intravenously injected poly(amino acid) nanoformulation relieves spinal cord injury through synergistical modulation of microenvironments.

ABSTRACT: The microenvironments play a crucial role in secondary injury following spinal cord injury (SCI). Deterioration of the microenvironments, including oxidative stress, inflammation, and excitotoxicity, exacerbates SCI. However, due to the complexity of these microenvironments, synergistic modulation of multiple factors remains challenging. In this study, we developed a reactive oxygen species (ROS) responsive nanoformulation system based on a methoxy poly(ethylene glycol)-block-poly(L-methionine-co-L-glutamic acid) copolymer (PME) and loaded it with minocycline (PME@Mino) to promote SCI repair. This nanoformulation was administered intravenously, accumulating at the lesion site where PME@Mino was exposed to ROS, triggering the release of minocycline. Through the synergistic mod

SUBMITTER: Li Y 

PROVIDER: S-EPMC12398927 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature