Multifunctional and endogenous stimuli-responsive vinblastine sulfate/manganese dioxide nanodrugs for enhancing chemotherapeutic efficacy against hypoxic tumors.

ABSTRACT: Several solid tumors contain large hypoxic regions, diminishing drug responses and resulting in limited therapeutic outcomes. Vinblastine sulfate (VBL) targets the tubulin molecule, causing microtubule depolymerization and inducing mitotic arrest, leading to tumor regression. However, hypoxia causes microtubule depolymerization in tumor cells, reducing the number of intact microtubules for drug binding and diminishing the efficacy of microtubule-targeting agents like VBL. Therefore, to relieve tumor hypoxia and enhance chemotherapeutic responses to hypoxic tumors, we developed multifunctional and endogenous stimuli-responsive VBL/manganese dioxide (VBL/MnO₂) nanodrugs. The VBL/MnO₂ nanodrugs demonstrated colloidal stability and were readily degraded by endogenous stim

SUBMITTER: Lim YG 

PROVIDER: S-EPMC12398928 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature