Manganese-dependent iron-superoxide dismutase drives Acinetobacter baumannii fitness during oxidative stress.

ABSTRACT: Superoxide dismutase (SOD), a widely distributed metalloenzyme across all domains of life, mitigates the harmful effects of reactive oxygen species generated during oxidative stress. The catalytic activity of SOD depends on specific metal cofactor, which is determined by bioavailability, structural compatibility, and environmental factors. The nosocomial pathogen Acinetobacter baumannii has been able to thrive under oxidative stress with SODs imparting a major role in curbing this distress. However, the functional role of two encoded SODs, namely SodB and SodC in A. baumannii, is poorly understood in mitigating oxidative stress. Furthermore, the metal ion specificities of these SodB and SodC families exemplify a knowledge gap, as the metal ion utilized by individual family members cannot b

SUBMITTER: Ray AK 

PROVIDER: S-EPMC12398933 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature