SATURN MRI: study protocol for the statin use in intracerebral hemorrhage patients MRI ancillary study.

ABSTRACT:

Background

The benefit-risk of statins in patients with lobar intracerebral hemorrhage (ICH) is under investigation in the StATins Use in intRacerebral hemorrhage patieNts (SATURN) trial. The relationship between statin use in ICH survivors, MRI markers of cerebral small vessel disease (CSVD), and outcomes such as recurrent ICH or major adverse cardiovascular or cerebrovascular events (MACCE) is unclear. The ancillary study, SATURN-MRI, intends to evaluate the interrelationship between statin use, the progression of MRI markers of CSVD, and cognitive and functional outcomes. Additionally, SATURN-MRI aims to assess whether baseline MRI markers of CSVD interact with statin continuation for the outcomes of recurrent ICH or MACCE in patients with lobar ICH.

Methods

A target of 8

SUBMITTER: Marchina S 

PROVIDER: S-EPMC12398981 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature