Outcomes of stereotactic body radiotherapy for unresectable cholangiocarcinoma: a meta-analysis and systematic review.

ABSTRACT:

Background

Stereotactic body radiotherapy (SBRT) is an effective treatment for various malignancies. This meta-analysis aimed to determine the prognostic outcomes and toxicities of SBRT for unresectable cholangiocarcinoma (CC) using the most recent evidence.

Methods

The review protocol was registered on PROSPERO (CRD42023393642). We searched PubMed, EMBASE, and the Cochrane Library for studies involving SBRT and CC. Study endpoints included median overall survival (OS), 1- and 2-year OS rates, 1- and 2-year disease control rates (DCR), and the incidence of grade 3 or higher toxicities.

Results

Thirteen studies (366 patients) were included. Of these, 138 patients (37.7%) had extrahepatic CC and 228 patients (62.3%) had intrahepatic CC. The median total SBRT dose was 45

SUBMITTER: Liu P 

PROVIDER: S-EPMC12399086 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature