Systematic survey reveals general applicability of "guilt-by-association" within gene coexpression networks.

ABSTRACT:

Background

Biological processes are carried out by coordinated modules of interacting molecules. As clustering methods demonstrate that genes with similar expression display increased likelihood of being associated with a common functional module, networks of coexpressed genes provide one framework for assigning gene function. This has informed the guilt-by-association (GBA) heuristic, widely invoked in functional genomics. Yet although the idea of GBA is accepted, the breadth of GBA applicability is uncertain.

Results

We developed methods to systematically explore the breadth of GBA across a large and varied corpus of expression data to answer the following question: To what extent is the GBA heuristic broadly applicable to the transcriptome and conversely how broadly is GB

SUBMITTER: Wolfe CJ 

PROVIDER: S-EPMC1239911 | biostudies-literature | 2005 Sep

REPOSITORIES: biostudies-literature