Unveiling the renoprotective mechanisms of self-assembled herbal nanoparticles from <i>Scutellaria barbata</i> and <i>Scleromitrion diffusum</i> in acute kidney injury: A nano-TCM approach.

ABSTRACT: Acute kidney injury (AKI) is a critical clinical condition characterized by rapid renal function decline, with high morbidity, mortality, and healthcare costs. Traditional Chinese medicine (TCM) has shown potential effects on mitigating oxidative stress and programmed cell death in AKI models. Scutellaria barbata D. Don (SB) and Scleromitrion diffusum (Willd.) R. J. Wang (SD), a classic TCM herbal pair exhibited anti-inflammatory and antioxidant activities. Using advanced chromatographic separation technology, we enriched the effective fractions of water extracts from SB-SD, obtaining self-assembled herbal nanoparticles (SB and SD nanoparticles, SSNPs) rich in flavonoids and terpenoids. These SSNPs demonstrated robust antioxidant properties in vitro and mitigated AKI p

SUBMITTER: Xia L 

PROVIDER: S-EPMC12399204 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature