Dynamic properties of network motifs contribute to biological network organization.

ABSTRACT: Biological networks, such as those describing gene regulation, signal transduction, and neural synapses, are representations of large-scale dynamic systems. Discovery of organizing principles of biological networks can be enhanced by embracing the notion that there is a deep interplay between network structure and system dynamics. Recently, many structural characteristics of these non-random networks have been identified, but dynamical implications of the features have not been explored comprehensively. We demonstrate by exhaustive computational analysis that a dynamical property--stability or robustness to small perturbations--is highly correlated with the relative abundance of small subnetworks (network motifs) in several previously determined biological networks. We propose that robust

SUBMITTER: Prill RJ 

PROVIDER: S-EPMC1239925 | biostudies-literature | 2005 Nov

REPOSITORIES: biostudies-literature