Rapid discovery of drug-introduced multiple organ dysfunction <i>via</i> NIR-II fluorescent imaging.

ABSTRACT: The precise and rapid monitoring of multiple organ dysfunction is crucial in drug discovery. Traditional methods, such as pathological analysis, are often time-consuming and inefficient. Here, we developed a multiplexed near-infrared window two (NIR-II) fluorescent bioimaging method that allows for real-time, rapid, and quantitative assessment of multiple organ dysfunctions. Given that existing probes did not fully meet requirements, we synthesized a range of NIR-II hemicyanine dyes (HDs) with varying absorption and emission wavelengths. By modifying these dyes, we achieved high spatial and temporal resolution imaging of the liver, kidneys, stomach, and intestines. This method was further applied to investigate disorders induced by cisplatin, a drug known to cause gastric emptying issues a

SUBMITTER: Jiang P 

PROVIDER: S-EPMC12399263 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature