Suppression of Paclitaxel-Induced Neuropathy and Ovarian Tumor Growth by Mn Porphyrin, MnTnBuOE-2-PyP⁵⁺ (BMX-001).

ABSTRACT: Numerous cellular and animal studies demonstrated the ability of redox-active Mn(III) N-alkyl- and N-alkoxyalkylpyridyporphyrins (MnPs) to protect normal tissue while suppressing tumor growth. The mechanism primarily involves the modulation of NF-кB and Nrf2 signaling pathways via catalysis of MnP/H₂O₂-driven protein thiol oxidation. Such differential protection/suppression effects have paved the way of Mn porphyrins (commonly known as mimics of superoxide dismutase) into clinical trials, therefore introducing new line of therapeutics that are affecting cellular redox status/oxidative stress, rather than specific proteins. The most clinically advanced Mn porphyrin, Mn(III) meso-tetrakis(N-n-butoxyethyl-2-pyridyl) porphyrin (MnTnBuOE-2-PyP

SUBMITTER: Spasojevic I 

PROVIDER: S-EPMC12399357 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature