Hepatic metabolism of 11-oxygenated androgens in humans: an integrated in vivo and ex vivo approach.

ABSTRACT:

Objective

Excess production of adrenal-derived 11-oxygenated androgens is observed in congenital adrenal hyperplasia, premature adrenarche, and polycystic ovary syndrome. 11-Ketotestosterone is equipotent to testosterone but does not decline with age. To date, the precise hepatic metabolism of 11-oxygenated androgens and subsequent urinary metabolite excretion have not been characterised.

Design

We employed an integrated approach combining an in vivo oral androgen challenge with an ex vivo normothermic machine liver perfusion (NMLP) model to characterise human hepatic 11-oxygenated androgen metabolism.

Methods

Women with polycystic ovary syndrome were randomised to receive 150 mg of either oral dehydroepiandrosterone or 11-ketoandrostenedione (11KA4) for 7 days (n = 1

SUBMITTER: McDonnell T 

PROVIDER: S-EPMC12399390 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature